The cost of persistence: MEK and metabolic demand.

Authors

Ewelina Sobierajska, Christopher B Medina

Published in

Immunity. Volume 59. Issue 8. Pages 2058-2060. Aug 11, 2026.

Abstract

The metabolic mechanisms linking chronic TCR stimulation to T cell exhaustion remain incompletely understood. Mitra and colleagues show that sustained MEK signaling drives the bioenergetic demands of chronic activation to promote terminal exhaustion, whereas MEK inhibition maintains progenitor-like T cells.

PMID:
42580317
Bibliographic data and abstract were imported from PubMed on 12 Aug 2026.

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