Authors
Tiantian Chen, Panyu Du, Yuning Liu, Xuefei Chen, Zheng Wang, Xin Li, Xiujie Zhao, Yanjun Zhao
Published in
Advanced healthcare materials. Pages e71575. Aug 11, 2026. Epub Aug 11, 2026.
Abstract
Ferroptosis is an iron-dependent form of regulated cell death that has emerged as one of the mechanisms underlying cisplatin-induced nephrotoxicity. Here, we report an iron-chelating polymeric micelle for controlled cisplatin activation and ferroptosis suppression to address the above issue. The block copolymer, methoxyl polyethylene glycol-poly(glutamic acid) (mPEG-PGlu) was coupled with an iron chelator, deferiprone (Dfp) to generate the tailored amphiphilic conjugate, mPEG-P(Glu-Dfp) that could coordinate with activated cisplatin and self-assemble into micelles (Pt@MDfp). The cisplatin-loaded mPEG-PGlu micelles (Pt@MGlu) and free cisplatin were employed as controls. Upon endocytosis, the intracellular labile iron could replace cisplatin due to the higher affinity between Dfp and Fe2+. This coordination exchange resulted in controlled cargo release and suppressed lipid peroxidation and inflammation in renal tubular cells (HK-2). The proof-of-concept was also validated in the subcutaneous 4T1 mouse breast tumor model using plasma and urine biomarkers of ferroptosis, inflammation, and renal injury as the indices, which concurred well with the histological staining of kidney tissue and fibrosis assessment. Moreover, due to the controlled cargo activation, Pt@MDfp significantly enhanced the in vivo antitumor efficacy compared to Pt@MGlu and free cisplatin. Collectively, the coordination exchange approach is promising in controlled delivery of cisplatin for efficacy enhancement.
PMID:
42581566
Bibliographic data and abstract were imported from PubMed on 12 Aug 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 1
- Comments 0