Age-Stratified Outcomes of Off-Clamp Robot-Assisted Partial Nephrectomy: A Comparison of Patients Younger Than 65 Years and Those Aged 65 Years or Older.

Authors

Oh Jun Yun, Jun-Koo Kang, Sang Hyub Lee, Yun-Sok Ha, Seock Hwan Choi, Bum Soo Kim, Hyun Tae Kim, Tae-Hwan Kim, Eun Sang Yoo, Tae Gyun Kwon, Jae-Wook Chung

Published in

Journal of laparoendoscopic & advanced surgical techniques. Part A. Pages 10926429261479471. Aug 11, 2026. Epub Aug 11, 2026.

Abstract

Evidence for completely off-clamp robot-assisted partial nephrectomy (RAPN) in older patients is limited. We compared age-stratified short-term outcomes.
We reviewed 146 consecutive patients who underwent off-clamp RAPN between June 2022 and March 2026: 99 were aged <65 years and 47 were aged ≥65 years. Outcomes included perioperative measures, 90-day major complications, postoperative day 1 (POD1) hemoglobin (Hb) decline, estimated glomerular filtration rate (eGFR) change, and surgical margin status. Parsimonious linear models adjusted for age group, baseline Hb or eGFR, tumor size, and RENAL score; expanded models were sensitivity analyses.
Older patients had more hypertension, diabetes mellitus, and cardiovascular disease and lower baseline Hb and eGFR (all P < .05). Console time, estimated blood loss, and length of stay did not differ significantly, and no major complication occurred. Positive margins occurred in 5/85 younger and 1/44 older patients with evaluable data (P = .663); margin status was unassigned in 17 nonmalignant cases. The median POD1 Hb decline was 1.0 versus 1.2 g/dL (P = .779), and the median 1-month eGFR change was 1.0 mL/min/1.73 m² in both groups (P = .746). In parsimonious models, neither age-group coefficient reached statistical significance: Hb decline, β = -0.01 (95% confidence interval [CI], -0.30 to 0.28; P = .937); 1-month eGFR change, β = -3.21 (95% CI, -6.80 to 0.38; P = .080).
No statistically significant age-group differences were detected in the evaluated short-term perioperative and functional outcomes. However, the confidence intervals, particularly for 1-month eGFR, did not exclude clinically relevant disadvantage in older patients and do not establish equivalence.

PMID:
42581025
Bibliographic data and abstract were imported from PubMed on 12 Aug 2026.

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