(2-Bromophenyl)boronates as C2 synthons in palladium-catalyzed three-component cascade [3+2] cyclization/C-H activation.

Authors

Yiyi Zheng, Shaojie Zhang, Shiyue Sun, Mingxia Wu, Yanfang Shang, Xin-Xing Wu

Published in

Chemical communications (Cambridge, England). Aug 12, 2026. Epub Aug 12, 2026.

Abstract

A palladium-catalyzed three-component cascade [3+2] cyclization/C-H activation using (2-bromophenyl)boronates as C2 building blocks is reported. The transformation utilizes azoles or polyfluoroarenes as distinct coupling partners to enable Suzuki-Miyaura coupling/Heck cyclization followed by C-H activation, offering an efficient and convenient route to functionalized fluorene derivatives. Moreover, this new approach exhibits excellent regioselectivity and broad substrate scope.

PMID:
42581801
Bibliographic data and abstract were imported from PubMed on 12 Aug 2026.

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