PLPPR3 and the making of neuronal filopodia.

Authors

Thomas J Böddeker, George Leondaritis, Britta J Eickholt

Published in

Biological chemistry. Aug 13, 2026. Epub Aug 13, 2026.

Abstract

Phospholipid phosphatase-related protein 3 (PLPPR3) is a regulator of neuronal membrane dynamics and cytoskeletal remodeling. In this review, we synthesize current evidence positioning PLPPR3 as a key driver of neuronal filopodia formation, highlighting its roles in lipid signaling, membrane protrusion and actin organization. By consolidating recent molecular, cellular, and functional studies, we propose a mechanistic framework for PLPPR3-dependent filopodia formation and outline its implications for neuronal morphogenesis.

PMID:
42584089
Bibliographic data and abstract were imported from PubMed on 12 Aug 2026.

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