Association between brain natriuretic peptide and invasive hemodynamics in left ventricular assist device HeartMate3-supported patients.

Authors

Elie Kozaily, Azalfa Lateef, Vishal N Rao, Gregory R Jackson, Anthony P Carnicelli, Chakradhari Inampudi, Lucas Witer, Mabelissa Geagea, Arman Kilic, Walker Blanding, Ryan J Tedford, Brian A Houston

Published in

The International journal of artificial organs. Pages 3913988261473044. Aug 12, 2026. Epub Aug 12, 2026.

Abstract

We report a serum BNP cut-off of 800 pg/mL above which all patients with LVAD HeartMate-3 had elevated biventricular filling pressures, suggesting it may be used to prompt invasive ramp study during routine post-LVAD clinic visit. We found stepwise increase in BNP levels across hemodynamic groups, with the lowest levels in patients with normal filling pressures, intermediate in those with elevated right or left-sided filling pressure and highest in those with elevated biventricular filling pressures. Furthermore, most patients with BNP above median value (335 pg/mL) required speed changes for either elevated right sided or left sided filling pressures. Conversely, patients with BNP below 335 pg/mL rarely required speed change. In conclusion, elevated serum BNP in patients with durable LVAD HeartMate-3 may have clinical value in prompting invasive hemodynamic assessment.

PMID:
42584206
Bibliographic data and abstract were imported from PubMed on 12 Aug 2026.

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