Authors
Aysu Okumuş Güçlü, Orbay Tutku Seren, Barış Gezici, Papatya Bayrak Değirmenci
Published in
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. Pages 10781552261478571. Aug 12, 2026. Epub Aug 12, 2026.
Abstract
Introduction5-Fluorouracil (5-FU) is an antimetabolite widely used in colorectal, gastric, breast, and other solid tumors. Hypersensitivity reactions are uncommon but may be severe.Case ReportWe report a 63-year-old woman with metastatic sigmoid colon cancer who developed an anaphylactic reaction during the second course of a 5-FU-containing regimen, specifically following the bolus infusion. Skin prick and intradermal tests performed four weeks later were negative.Management & OutcomeAs no equally efficacious alternative existed within the planned regimen, rapid intravenous desensitization was performed using a 16-step protocol with four dilution solutions. Desensitization was completed without adverse events, and the subsequent 48-h continuous 5-FU infusion was also well tolerated.DiscussionThis case adds to the limited literature on 5-FU desensitization and underscores its feasibility and safety in agent-dependent patients.
PMID:
42585552
Bibliographic data and abstract were imported from PubMed on 13 Aug 2026.
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