Executive summary of the consensus document for recommendations on the treatment of venous thromboembolism in pregnancy: consensus document from the Spanish Society of Internal Medicine, the Spanish Society of Medical Radiology, the Spanish Society of Vascular Interventional Radiology and the Spanish Society of Gynecology and Obstetrics 2026.

Authors

M Á Fidalgo-Fernández, M Ortiz-Rodríguez, S Moragón-Ledesma, S Lojo-Lendoiro, P Demelo-Rodriguez, M Grau-García, M Martín-Asenjo, B Serrano-Sánchez, N Martínez-Sánchez, O Madridano-Cobo, E Gálvez-González, F Galeano-Valle

Published in

Revista clinica espanola. Pages 502613. Aug 12, 2026. Epub Aug 12, 2026.

Abstract

Low-molecular-weight heparin is the anticoagulant treatment of choice for managing venous thromboembolism (VTE) during pregnancy and lactation. Vitamin K antagonists are contraindicated between weeks 6-12 of gestation due to their association with a specific embryopathy, and during the third trimester due to the risk of bleeding. Direct oral anticoagulants are contraindicated during pregnancy and breastfeeding because of the risk of prenatal malformations. Reperfusion techniques, such as systemic thrombolysis or mechanical thrombectomy, are reserved for cases of pulmonary embolism with hemodynamic instability.
This consensus document, developed by the Spanish Societies of Internal Medicine, Medical Radiology, Vascular and Interventional Radiology, and Gynecology and Obstetrics, provides a comprehensive review of the most recent evidence on the treatment of VTE in pregnant patients and updates current recommendations. [[es]]Resumen INTRODUCCIóN: La heparina de bajo peso molecular es el tratamiento anticoagulante de elección para el tratamiento de la enfermedad tromboembólica venosa (ETV) durante la gestación y la lactancia. Los antagonistas de vitamina K están contraindicados durante las semanas 6-12 por relacionarse con una embriopatía específica y en el tercer trimestre por el riesgo hemorrágico. Los anticoagulantes orales de acción directa están contraindicados en el embarazo y la lactancia por riesgo de malformaciones prenatales. Técnicas de reperfusión, como la fibrinólisis sistémica o la trombectomía mecánica, se reservan para casos de embolia pulmonar con inestabilidad hemodinámica. MéTODOS Y RESULTADOS: Este documento de consenso, elaborado por las Sociedades Españolas de Medicina Interna, de Radiología Médica, de Radiología Vascular e Intervencionista y de Ginecología y Obstetricia, realiza una revisión exhaustiva de la evidencia más reciente sobre el tratamiento de la ETV en la paciente gestante y actualiza las recomendaciones.

PMID:
42586421
Bibliographic data and abstract were imported from PubMed on 13 Aug 2026.

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