Authors
Waha Ismail Yahia Abdelmula, Babbiker Mohammed Taher Gorish, Bin Liu, Wenqian Dang, Yue Bai, Daochen Zhu
Published in
Carbohydrate polymers. Volume 389. Pages 125664. Oct 01, 2026. Epub Jul 21, 2026.
Abstract
Infected diabetic wounds face a dual therapeutic challenge of rapid biomaterial degradation under combined oxidative-osmotic stress, and mechanical collapse of conventional redox-active polysaccharide gels upon prolonged wet-state exposure. To address these challenges, we engineered a tri-domain phyto-cryogel integrating oxidized lignin, gum Arabic, and Aloe vera into an interpenetrating architecture. A covalently crosslinked poly (N-vinylpyrrolidone-co-N,N'-methylenebisacrylamide) [poly(NVP-co-MBAM)] backbone provides wet-state persistence. At the same time, hydrogen-bond-rich polysaccharide domains maintain hydration under hyperosmotic challenge, and lignin-derived phenolic motifs contribute radical-scavenging capacity. The tri-domain cryogel retained consistent antioxidant activity across seven 2,2-diphenyl-1-picrylhydrazyl (DPPH) cycles (82.4 ± 0.6% to 81.0 ± 0.2%, p > 0.05), whereas binary preparations showed significant decay. In an infected diabetic animal model, the lignin-gum Arabic-Aloe vera (LGA) 0.2% tri-domain cryogel accelerated early-stage wound closure compared to a medical-grade bandage control (38.6% vs. 19.3% by Day 3, p < 0.01), accompanied by reduced cluster of differentiation 68 (CD68) macrophage infiltration, normalized redox ratios, and enhanced angiogenesis. These findings demonstrate that polymer architecture-driven microenvironment buffering, through integrated mitigation of oxidative stress, osmotic stress, and infection, can accelerate diabetic wound healing without relying on drug delivery.
PMID:
42586690
Bibliographic data and abstract were imported from PubMed on 13 Aug 2026.
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