Evidence of the Warburg Effect During Glioblastoma Resection Resulting in Severe Lactic Acidosis: A Case Report.

Authors

Alexander C Fort, Mark Jessup, Miguel Cobas

Published in

A&A practice. Volume 20. Issue 8. Pages e02226. Aug 01, 2026. Epub Aug 12, 2026.

Abstract

The Warburg effect describes the phenomenon in which cancer cells preferentially use glycolysis even under aerobic conditions, leading to excessive lactate production. Though more frequently described in hematologic malignancies, this mechanism can also be seen in solid tumors. Here we report a case of an 84-year-old man who developed a profound intraoperative lactic acidosis during glioblastoma resection, likely attributable to the Warburg effect. This case highlights the importance of maintaining broad differential diagnoses of lactic acidosis. Anesthesiologists, surgeons, and intensivists should be aware of this phenomenon, as failure to recognize the diagnosis may result in unnecessary and potentially harmful interventions.

PMID:
42593427
Bibliographic data and abstract were imported from PubMed on 13 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.