Authors
Ester Maduma Napitupulu, Malayana Rahmita Nasution, Andriamuri Primaputra Lubis, Nindia Sugih Arto, Ranti Permatasari
Published in
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina. Volume 23. Issue 2. Jul 29, 2026. Epub Jul 29, 2026.
Abstract
To assess the correlations of neutrophil reactivity intensity (NEUT-RI) and neutrophil granularity intensity (NEUT-GI) with the Sequential Organ Failure Assessment (SOFA) score in adults with sepsis.
This cross-sectional study included 52 adult inpatients with sepsis at H. Adam Malik General Hospital, Medan, Indonesia, in September 2025. NEUT-RI and NEUT-GI were measured using a Sysmex XN-1000 haematology analyser, and SOFA scores were obtained from medical records. Associations were analysed using Pearson correlation and linear regression. Receiver-operating-characteristic (ROC) analysis for SOFA ≥6 was exploratory because the cut-off was derived and evaluated in the same sample.
The median age was 56 years (IQR 46-64), 29/52 (55.8%) participants were male, and the median SOFA score was 6 (IQR 4-8). NEUT-RI correlated strongly with the SOFA score (r = 0.819; 95% CI 0.704-0.893; R² = 0.671; p < 0.001) and remained independently associated after adjustment for age, sex, NEUT-GI, and log-transformed leukocyte count (B = 0.370; 95% CI 0.294-0.446; standardised β = 0.82; p < 0.001). Exploratory ROC analysis yielded an in-sample AUC of 0.994 for SOFA ≥6 at a cut-off of 49.9 FI. NEUT-GI was not significantly associated with SOFA (r = 0.068; p = 0.631).
NEUT-RI, but not NEUT-GI, was independently associated with concurrent organ-dysfunction severity in adults with sepsis. Prospective validation is required before clinical application.
PMID:
42592985
Bibliographic data and abstract were imported from PubMed on 13 Aug 2026.
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