Isolated Major Organ Involvement as the Initial Presentation of Systemic Lupus Erythematosus: A Diagnostic Challenge from a Tertiary Care Center.

Authors

Shweta Suryakant Khopde, Ashish Mohan Vidhate

Published in

Annals of African medicine. Aug 14, 2026. Epub Aug 14, 2026.

Abstract

Systemic lupus erythematosus (SLE) typically presents with multisystem involvement; however, some patients present with isolated major organ disease, leading to diagnostic delay.
The objective of this study was to evaluate the frequency, clinical characteristics, and immunological profile of SLE patients presenting with isolated major organ involvement at disease onset.
Adult patients fulfilling the Systemic Lupus International Collaborating Clinics 2012 criteria were evaluated. Patients presenting with isolated renal, neuropsychiatric, or cardiopulmonary involvement without classical features were identified.
Out of 45 SLE patients, 18 (40%) presented with isolated major organ involvement. Renal involvement was the most common isolated presentation. All patients showed antinuclear antibody positivity and hypocomplementemia.
Isolated major organ involvement is a common and diagnostically challenging initial presentation of SLE.

PMID:
42593237
Bibliographic data and abstract were imported from PubMed on 13 Aug 2026.

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