Risk factors and microbiological profile of ventilator-associated pneumonia in a tertiary-care intensive care unit in Tuzla: a prospective observational study.

Authors

Minela Becirovic, Emir Becirovic, Jusuf Hodžić, Amir Becirovic, Elma Mujaković, Admir Abdić, Radojka Golijan

Published in

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina. Volume 23. Issue 2. Jul 08, 2026. Epub Jul 08, 2026.

Abstract

To determine the prevalence and microbiological profile of ventilator-associated pneumonia (VAP) in mechanically ventilated patients and to assess clinical and laboratory parameters associated with its development, with emphasis on C-reactive protein (CRP) levels and duration of mechanical ventilation.
This single-centre prospective observational cohort study included 118 adult patients who required invasive mechanical ventilation for more than 48 hours in the intensive care unit of the University Clinical Centre Tuzla. Patients were classified into VAP and non-VAP groups. Demographic, clinical, laboratory, and microbiological data were collected, and in-hospital outcomes were recorded. Statistical analysis included between-group comparisons, univariate logistic regression, and receiver operating characteristic (ROC) curve analysis.
VAP was diagnosed in 41 patients (34.7%). Gram-negative pathogens predominated (≈ 85%), with Acinetobacter baumannii identified most frequently (43.9%), followed by Pseudomonas aeruginosa and Klebsiella pneumoniae. Patients with VAP had significantly longer durations of mechanical ventilation (12.5 vs. 7.3 days, p < 0.001) and hospitalisation (19.6 vs. 12.2 days, p < 0.001), as well as higher CRP levels (178.2 vs. 126.4 mg/L, p < 0.001). Reintubation, elevated CRP, leukocytosis, hypercapnia, and prolonged mechanical ventilation were associated with VAP. CRP demonstrated good-to-moderate discriminative ability for VAP (AUC = 0.83).
VAP remains a common and clinically significant complication in mechanically ventilated patients. Elevated CRP levels and prolonged mechanical ventilation may support early clinical suspicion using routinely available parameters.

PMID:
42592972
Bibliographic data and abstract were imported from PubMed on 13 Aug 2026.

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