Authors
Minghui Shi, Xiang Li, Jiale Li, Yao Huang, Wenrui Wang, Liuqing Di, Jun Chen, Ruoning Wang
Published in
Journal of controlled release : official journal of the Controlled Release Society. Pages 115258. Aug 13, 2026. Epub Aug 13, 2026.
Abstract
As an important barrier tissue, the intestinal mucosa is responsible for regulating immunity, absorbing nutrients, and maintaining microbial homeostasis. Structural damage or functional impairment of the mucosa not only leads to a series of mucosa-related diseases but also may cause pathological changes in extramucosal organs. Given the central role of mucosal dysfunction in the onset and progression of various diseases, effectively regulating mucosal function and improving drug delivery efficiency are critical for improving clinical outcomes in gastroenterology. This article systematically reviews the structural characteristics and main functions of the intestinal mucosa, and analyzes the manifestations and underlying mechanisms of mucosal dysfunction. Based on this, we summarize recent advances in barrier enhancement, precise tissue and cell-level targeting, and microenvironment-responsive delivery strategies, and further elaborate on the latest progress in bio-inspired nanosystems for the treatment of gastrointestinal diseases. Finally, this article discusses the clinical trial progress, current challenges, and future development prospects of artificial intelligence optimization technology in the regulation of intestinal mucosa and drug delivery, aiming to provide theoretical basis and research references for in-depth studies on the regulation of intestinal mucosa function and the clinical application of related delivery systems.
PMID:
42595183
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.
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