CXCR4-Targeted Molecular Imaging in Hematology and Oncology.

Authors

Rudolf A Werner, Andreas K Buck, Alexander Haug, Francoise Kraeber-Bodéré, Constantin Lapa, Margret Schottelius, Sebastian E Serfling, Takahiro Higuchi, Caroline Bodet-Milin, Markus Raderer, Simone Wegen, Martin G Pomper, Christophe M Deroose, Ken Herrmann, Ulrich Keller, Carsten Kobe, Martin Gotthardt

Published in

Journal of nuclear medicine : official publication, Society of Nuclear Medicine. Aug 13, 2026. Epub Aug 13, 2026.

Abstract

C-X-C motif chemokine receptor 4 (CXCR4) has emerged as a powerful imaging target in nuclear oncology. In this regard, the PET agent [⁶⁸Ga]Ga-pentixafor is promising but still evolving. In this article, we provide an overview of potentially useful imaging applications for CXCR4-targeted imaging in hemato-oncology and guidance on scan interpretation by discussing diagnostic pitfalls. We also report on theranostic efforts and how the field has been expanded toward the imaging of solid tumors. As such, this review focuses on potential clinical integration of CXCR4-targeted molecular imaging across multiple disease entities, particularly in the field of hemato-oncology.

PMID:
42595488
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.

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