[Expert consensus on DNA methylation sample processing and detection technology].

Authors

Laboratory Medicine Committee,Chinese Association of Integrative Medicine, Molecular Diagnostics Group, Chinese Society of Laboratory Medicine, Chinese Medical Association, Precision Medicine Committee, Beijing Association of the Integrating of Traditional and Western Medicine

Published in

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. Volume 60. Issue 8. Pages 1217-1235. Aug 06, 2026.

Abstract

DNA methylation represents one of the most prevalent and significant epigenetic modifications in humans, playing a crucial role in numerous physiological and pathological processes within the human body. It demonstrates considerable potential as a novel disease biomarker. DNA methylation testing involves diverse sample types and complex procedures, with no unified standards currently established for its workflow. Consequently, developing a consensus on sample processing and detection techniques for DNA methylation holds significant value for advancing technological development, clinical translation, and application in this field. This consensus document, jointly authored by the Laboratory Medicine Committee of the Chinese Association of Integrative Medicine, the Molecular Diagnostics Group of the Chinese Society of Laboratory Medicine of Chinese Medical Association, and the Precision Medicine Committee of the Beijing Association of the Integrating of Traditional and Western Medicine, synthesizes the perspectives and expertise of specialists of laboratory medicine and pathology. The present document provides detailed guidance on key aspects such as the definition of DNA methylation, sample collection and pre-processing, nucleic acid extraction and conversion, methylation detection, and reporting of results. Fourteen consensus statements have been distilled from this comprehensive framework.

PMID:
42595530
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.

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