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Rethinking neurovascular coupling in white matter.

Created on 14 Aug 2026

Authors

Carlos Matute

Published in

Trends in endocrinology and metabolism: TEM. Aug 13, 2026. Epub Aug 13, 2026.

Abstract

Neurovascular coupling (NVC) is associated with activity-dependent functional hyperemia in gray matter. White matter may operate under distinct vascular-metabolic principles. We propose that white matter operates through a reserve-based form of NVC in which local energetic reserves help sustain energy homeostasis despite transient mismatches between metabolic demand and vascular supply.

PMID:
42595639
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.

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