Authors
Otto Jesus Hernández Fustes, Cláudia Suemi Kamoi Kay, Paulo José Lorenzoni, Renata Dal-Prá Ducci, Paula Raquel do Vale Pascoal Rodrigues, Orlando Graziani Povoas Barsottini, Rosana Herminia Scola
Published in
Arquivos de neuro-psiquiatria. Volume 84. Issue 7. Pages 1-7. Epub Aug 13, 2026.
Abstract
Cutaneous wrinkling is a normal phenomenon that occurs on the palms in a reversible manner and results from vasoconstriction influenced by vasomotor function. It can be assessed through the skin-wrinkling test following water immersion, with the absence or reduction of wrinkling being associated with disorders affecting the dense network of sympathetic nerves in these regions. The literature suggests that this test may serve as a screening tool for small-fiber neuropathy, particularly in settings in which biopsy is not available. It is a rapid, inexpensive, and easily-accessible test. We herein review the principles of the skin-wrinkling test, its pathophysiology, and its clinical indications as a tool to evaluate the sympathetic component of the autonomic nervous system.
PMID:
42595323
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.
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