Authors
Yongchang Qiao, Zhiyuan Ma, Maomao He, Dongmei Xi, Xin Zhao, Yan Gao, Jiangli Fan, Wen Sun, Xiaojun Peng
Published in
Advanced healthcare materials. Pages e71585. Aug 13, 2026. Epub Aug 13, 2026.
Abstract
Colorectal cancer (CRC) is a highly prevalent malignancy worldwide. Early diagnosis remains challenging, and its strong propensity for metastasis is a major contributor to poor patient prognosis. Current approaches for surgical guidance and photodynamic therapy (PDT) in CRC are hindered by key limitations. Imaging techniques used for intraoperative navigation often lack sufficient sensitivity and specificity, while conventional PDT often employs "always-on" photosensitizers that lack tumor selectivity, posing a risk of collateral damage to healthy tissues. To address these limitations, this study leveraged the overexpression of β-N-acetylhexosaminidase (Hex) in CRC to design and develop an activatable near-infrared phototheranostic probe (INA) for tumor diagnosis and therapy. In vitro experiments demonstrated that INA is effectively activated by endogenously overexpressed Hex in CRC cells. Under light irradiation, it exhibits potent phototoxicity against CRC cells and three-dimensional tumor spheroids, with minimal dark toxicity. In tumor-bearing mouse models, INA enabled tumor-specific fluorescence imaging, real-time detection of microtumors for surgical navigation, and effective PDT, while demonstrating favorable biocompatibility. With its simple molecular architecture, INA is positioned as a highly competitive and readily translatable candidate for integrated diagnosis and therapy in CRC.
PMID:
42596506
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.
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