Development of a predictive model for visual outcomes and risk factors of bilateral involvement for non-arteritic anterior ischemic optic neuropathy (NAION) in Chinese patients.

Authors

Xintong Xu, Mingming Sun, Shanshan Cao, Chunyan Pan, Yuhang Wang, Biyue Chen, Andrew G Lee, Jost Jonas, Quangang Xu, Shihui Wei, Huanfen Zhou

Published in

Eye and vision (London, England). Volume 13. Issue 1. Aug 14, 2026. Epub Aug 14, 2026.

Abstract

This study aimed to explore the risk factors associated with bilateral involvement and to develop a predictive model for visual prognosis in Chinese patients with non-arteritic anterior ischemic optic neuropathy (NAION).
In this retrospective database-related meta-analysis, we retrospectively identified patients with NAION from the Chinese Neuro-Ophthalmic Diseases project database between September 2020 and December 2024. The clinical characteristics of the patients were summarized. Logistic and stepwise regression analyses were performed to identify the factors associated with bilateral involvement. Patients were randomly divided into training (75%) and validation (25%) cohorts. Least absolute shrinkage and selection operator (LASSO) and logistic regression analyses were used to develop a model for predicting factors associated with a best-corrected visual acuity (BCVA) ≤ 0.3 (decimal).
The study included 895 patients (560 [62.57%] males, 1,128 eyes; mean age: 55.6 ± 10.4 years). Bilateral NAION was present in 226 (25.3%) patients. At the follow-up examination, 522 patients (730 eyes) had a BCVA ≤ 0.3 in 369 (50.6%) eyes. Bilateral NAION involvement was associated with hyperlipidemia (t = 2.02, P = 0.04), hematologic disorders (t = 2.31, P = 0.02), and smoking (t = 4.79, P < 0.01). Risk factors for a BCVA ≤ 0.3 at follow-up were a lower BCVA at onset (odds ratio [OR] = 0.72, 95% confidence interval [CI]: 0.64-0.82, P < 0.01), diabetes mellitus (OR = 2.97, 95% CI: 1.10-8.03, P = 0.03), hyperhomocysteinemia (OR = 11.59, 95% CI: 1.87-71.97, P = 0.01), and macular serous detachment (OR = 6.70, 95% CI: 1.34-33.40, P = 0.02). The area under the receiver operating characteristic curve was 0.87 (95% CI: 0.83-0.87) for the training cohort and 0.86 (95% CI: 0.80-0.86) for the validation cohort.
Hyperlipidemia, hematologic disorders, and smoking were significant risk factors for bilateral NAION, whereas the severity of vision loss at onset, diabetes mellitus, hyperhomocysteinemia, and macular serous detachment were associated with poor visual prognosis in Chinese patients with NAION.

PMID:
42596023
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.

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