Risk Factors for Coronavirus Disease 2019 Hospitalization and Vaccination Impact Among Pediatric Solid Organ Transplant Recipients in the United States.

Authors

Sanya J Thomas, Natalia E Castillo Almeida, Claire Bocchini, Caitlin Brammer, Guy Brock, Abigail Calimaran, Ronald Dallas, Kevin J Downes, Jose A Ferrolino, Md Rejuan Haque, Anna R Huppler, Ishminder Kaur, Madan Kumar, Meghan Landry, Stacee Lerret, Gabriela M Maron, Timothy D Minniear, William J Muller, Flor M Munoz, William R Otto, Kerrigan Perkins, Elizabeth H Ristagno, Anna Sharova, Katherine Siegel, Eunkyung Song, Marion Jose Valladares, Natasha A Wilson, Allison Yoshida, Masako Shimamura

Published in

Transplant infectious disease : an official journal of the Transplantation Society. Pages e70303. Aug 13, 2026. Epub Aug 13, 2026.

Abstract

While vaccination is a key strategy to mitigate the severity of coronavirus disease 2019 (COVID-19) in children, the risk factors for symptomatic, medically attended (hereon referred to as "symptomatic") COVID-19 and the impact of vaccination are not well defined among pediatric solid organ transplant recipients (PSOTR).
PSOTR aged six months through 21 years at 11 centers in the Pediatric Infectious Diseases Transplant Network (PIDTRAN) were analyzed retrospectively for symptomatic COVID-19 between July 2021 and May 2023. Using a Cox proportional hazards model, risk factors associated with COVID-19-associated hospitalization, in-hospital oxygen use, mechanical ventilation, and the impact of COVID-19 vaccination were analyzed.
Of 1370 PSOTR, 410 (29%) had symptomatic COVID-19 infection. Among those with symptomatic infection, 115 (28%) were hospitalized, 35 required in-hospital oxygen, and three required mechanical ventilation. In the study, 45% were unvaccinated against COVID-19. Compared to unvaccinated PSOTR, incompletely vaccinated PSOTR had 56% lower hazard (95% CI 0.26, 0.72, p = 0.001) of COVID-19-associated hospitalization whereas completely vaccinated did not have a statistically significant difference in hazard of hospitalization. Receipt of at least one dose of the bivalent vaccine was also associated with 92.5% lower hazard (95% CI 0.010, 0.55, p = 0.011) of hospitalization. Risk factors for hospitalization included chronic kidney disease, underlying heart disease, neurodevelopmental delay, and lymphocytopenia.
Most PSOTR with symptomatic COVID-19 did not require hospitalization or respiratory support. Several comorbidities and lymphocytopenia are associated with severe COVID-19 in PSOTR. COVID-19 vaccination, mostly, protected PSOTR against COVID-19-associated hospitalization, but vaccine uptake among PSOTR was low.

PMID:
42596081
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.

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