Palladium-catalyzed construction of hybrid heterocycles by sequential cyclization of alkynyl insertion/olefin carboamination.

Authors

Tian Tang, Ruixin Chen, Shuaijie Wu, Shuwei Zhang, Lei Wang, Qiang Dai

Published in

Chemical communications (Cambridge, England). Aug 14, 2026. Epub Aug 14, 2026.

Abstract

A novel hybrid heterocyclic framework was successfully achieved through a sequential cyclization involving the palladium-catalyzed alkynyl insertion/olefin carboamination reaction from non-cyclic substrates, providing operable adjustable heterocyclic combinations and modifiable skeletons, featuring an efficient molecular queuing strategy under simple and mild conditions, and exhibiting a broad substrate scope and good synthetic versatility.

PMID:
42596810
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.

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