Allylic gem-diboronic esters: synthesis, reactivity, and applications in regio-, chemo-, and stereoselective C-C bond formation.

Authors

Kanak Kanti Das, Sutapa Dey

Published in

Chemical communications (Cambridge, England). Aug 14, 2026. Epub Aug 14, 2026.

Abstract

Recent advances in the synthesis and reactivity of allylic gem-diboronic esters have established these compounds as uniquely programmable nucleophiles for highly selective C-C bond formation across diverse reaction manifolds. Their dual boron functionality enables precise control over regio-, chemo-, and stereoselectivity under both metal-catalyzed and metal-free conditions. Efficient synthetic strategies have significantly expanded access to structurally diverse allylic gem-diboronic esters, while their reactivity has been broadly explored in 1,2- and 1,4-additions, nucleophilic aromatic substitution, carbon-heteroatom bond formation, and deborylative allylation-rearrangement cascades. Collectively, these advances establish allylic gem-diboronic esters as versatile and programmable synthetic platforms for the selective construction of densely functionalized and stereochemically complex molecular architectures.

PMID:
42596657
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.

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