Persistent circulation of Rift Valley fever virus lineage C in Rwanda, 2022-2025.

Authors

Jean Claude Udahemuka, Hayley Cassidy, Leonard Schuele, Evodie Uwibambe, Methode Gasana Ngabo, Leandre Murhula Masirika, Reuben Sindayiheba, Saria Otani, Misbah Gashegu, Jean-Claude Twizere, Frank Aarestrup, Fabrice Ndayisenga, Bas B Oude Munnink, Marion P G Koopmans, Pacifique Ndishimye

Published in

One health (Amsterdam, Netherlands). Volume 23. Pages 101529. Epub Aug 01, 2026.

Abstract

Rwanda has experienced recurrent Rift Valley fever virus outbreaks in the last decade. In this study, we investigated whether these outbreaks resulted from repeated introductions or sustained local circulation. We generated RVFV whole-genome sequences from livestock samples collected between 2022 and 2025 using Nanopore sequencing. Genomic analyses indicated the outbreaks resulted from sustained local circulation of lineage C rather than repeated introductions, suggesting ongoing transmission likely driven by sporadic spillover. This study underscores the importance of continuous genomic One Health surveillance in endemic settings.

PMID:
42598172
Bibliographic data and abstract were imported from PubMed on 14 Aug 2026.

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