The changing spectrum of cutaneous leishmaniasis and HIV coinfection in Bolivian Amazonia: a case report.

Authors

Alfonso Gotor-Rivera, Mayber Lenin Aparicio-Loayza, Rodrigo Federico Matilla Naumionek, José Luis Rodríguez Peralto, María René Melendres-Moscoso, Yolanda López-Ochoa

Published in

Transactions of the Royal Society of Tropical Medicine and Hygiene. Aug 14, 2026. Epub Aug 14, 2026.

Abstract

A 34-year-old man with advanced HIV infection presented with localized cutaneous leishmaniasis, after unsuccessful trestment with pentavalent antimonials, progressive dissemination ocurred . On re-evaluation, he exhibited numerous widespread ulcerated papules and nodules , accompanied by systemic symptoms and significant weight loss. Skin smears and histopathology demonstrated intracellular amastigotes. A diagnosis of intermediate cutaneous leishmaniasis with HIV coinfection was established. Treatment with liposomal amphotericin B followed by oral miltefosine led only to transitory clinical resolution.
This case highlights the diagnostic and therapeutic challenges of leishmaniasis in immunocompromised patients and underscores the dynamic nature of the clinical classification of cutaneous leishmaniasis.

PMID:
42600141
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.

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