Beyond Usage Time: Rethinking Therapeutic Dose and Effect in Digital Therapeutics.

Authors

Björn Meyer, Linda T Betz, Mario Weiss, Wolfgang Lutz

Published in

JMIR mental health. Volume 13. Pages e98660. Aug 14, 2026. Epub Aug 14, 2026.

Abstract

Digital therapeutics (DTx) have become increasingly prominent in mental health care, offering scalable, evidence-based interventions. A common assumption underlying their design and evaluation is that greater usage time leads to superior therapeutic outcomes, reflecting an implicit linear dose-response model. However, accumulating evidence challenges this simplified perspective and suggests that the relationship between usage time and clinical benefit is substantially more complex. In this viewpoint article, we critically examine the assumption that higher usage time is a necessary prerequisite for therapeutic success in digital mental health interventions. Drawing on psychotherapy dose-effect research, findings from digital intervention trials, and our own empirical work, we highlight several factors that complicate linear exposure models. These include rapid early response and plateau effects, substantial heterogeneity in user trajectories, motivational and contextual determinants of use, episodic patterns of engagement, and the distinction between on-platform activity and off-platform skill application. The linear dose metaphor, implicitly inherited from pharmacotherapy models, appears conceptually mismatched with learning-based digital interventions. Importantly, equating greater use with greater effectiveness risks conflating exposure with therapeutic mechanism, and may inadvertently promote evaluation frameworks that prioritize duration over meaningful change. Together, these insights suggest that usage time is an imperfect proxy for therapeutic engagement, and that high or continuous use should not be treated as a universal indicator of intervention quality. We argue for a shift toward mechanism-informed and individualized evaluation frameworks that prioritize the quality, timing, and functional impact of intervention use over cumulative exposure.

PMID:
42600086
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.

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