Natural Trichomes as a Functional Biomaterial Platform With Photoprotective and Regenerative Properties.

Authors

Jianmei Chen, Yifan Wu, Tiantian Zhu, Zongguang Liu

Published in

Journal of biomedical materials research. Part B, Applied biomaterials. Volume 114. Issue 8. Pages e70147.

Abstract

Effective skin repair and photoprotection require multifunctional, simple, and ready-to-use biomaterials. We focused on natural tea trichomes (TH), a class of plant-derived microfilaments abundantly distributed on tea leaves, as a potential candidate biomaterial that fulfills these criteria. TH exhibited a uniform fibrous morphology with a diameter of approximately 9.1 μm and a high polyphenol content of 176 μg/mg. In vitro ABTS⁺ and DPPH assays confirmed its effective radical scavenging capacity. In vivo studies demonstrated rapid hemostasis with negligible hemolysis, underscoring its biosafety. In a murine full-thickness wound model, TH significantly accelerated tissue regeneration, achieving 88.9% wound closure on day 10 versus 77.6% in controls, by promoting M1-to-M2 macrophage polarization, enhancing collagen deposition, and stimulating hair follicle neogenesis. Furthermore, TH, whether applied alone or blended into a hyaluronic acid (HA) matrix, effectively mitigated UV-induced epidermal hyperplasia, collagen degradation, and inflammatory cytokine expression. This work demonstrates that TH can serve as a sustainable, multifunctional platform for skin repair, with regenerative and photoprotective properties as its primary demonstrated functions.

PMID:
42601329
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.

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