Schisandrin B Attenuates Doxorubicin-Induced Acute Cardiac Injury through Regulation of Metabolites and Gut Microbiota.

Authors

Huixin Qiu, XiangYing Wang, Jun Qian, Shumin Zhang, Sitong Liu, MengJie Hong, Lexin Shu, Qiduo Zhao, Yubo Li

Published in

European journal of pharmacology. Pages 179246. Aug 14, 2026. Epub Aug 14, 2026.

Abstract

Schisandrin B (Sch B), a major bioactive lignan from the medicinal herb Schisandra chinensis, possesses anti-inflammatory and antioxidant properties. However, the mechanism by which it attenuates anthracycline (ANT)-induced acute cardiac injury remains elusive, particularly regarding systemic metabolite dynamics and gut microbiota modulation. Here, we integrate metabolomics with 16S rDNA high-throughput sequencing to investigate this cardioprotective effect. Our data reveal that Sch B alleviates ANT-induced cardiac injury through coordinated regulation of specific metabolic pathways and gut microbial composition. These findings establish a mechanistic basis for the clinical translation of Sch B and provide a framework for further mechanistic dissection of its multi-target actions.

PMID:
42601005
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.

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