Authors
Yuping Liu, Lihong Huang, Yujuan Huang, Binli Cai, Qianqing Fan, Xue Liu, Yayan Deng, Jiaxiang Ye, Fei Liu, Yongqiang Li, Jiazhang Wei, Jinyan Zhang
Published in
iScience. Volume 29. Issue 8. Pages 117070. Aug 21, 2026. Epub Aug 06, 2026.
Abstract
Epithelial-mesenchymal transition (EMT) is a reversible cellular program that allows epithelium-derived cells to acquire mesenchymal phenotypes, whereas mesenchymal-epithelial transition (MET) enables mesenchymal cells to regain epithelial properties. The capacity for EMT and MET, known as epithelial-mesenchymal plasticity (EMP), represents an indispensable mechanism of invasive plasticity for tumor progression during the spatiotemporal invasion-metastasis cascade. In this review, we elucidate the pivotal role of EMP in tumor metastasis and treatment resistance, as well as the latest understanding of the molecular mechanisms that regulate this cellular characteristic. We further summarize the methodology and technology for evaluating EMP and discuss the clinical translational potential of targeting EMP-related signaling pathways as a personalized anti-metastasis therapeutic strategy.
PMID:
42602989
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 1
- Comments 0