The Odf2 status contributes to asymmetric inheritance of CD133-positive recycling endosomes during cytokinesis in SK-N-DZ human neuroblastoma cells.

Authors

Hideki Izumi, Takao Mae, Sachiko Tsukita, Akira Nakagawara

Published in

iScience. Volume 29. Issue 8. Pages 117062. Aug 21, 2026. Epub Aug 06, 2026.

Abstract

Asymmetric cell division (ACD) is a physiological event that maintains development and tissue homeostasis. ACD generates two unequal daughter cells, one of which has stem cell properties while the other has differentiation potential. Recent studies show that the balance between self-renewal and differentiation is precisely controlled and that the disruption of this balance leads to diseases, such as tumors. Herein, we examined centrosome inheritance during cell division by using the human neuroblastoma cell line SK-N-DZ. The results showed that daughter cells inheriting daughter centrosomes with younger mother centrioles received more CD133-recycling endosomes, while those inheriting mother centrosomes with older mother centrioles received fewer CD133-recycling endosomes. The depletion of outer dense fiber protein 2/cenexin, which localizes to both centrosomal distal and subdistal appendages, strongly promoted the localization of recycling endosomes at both centrosomes, and ACD was lost. Therefore, these results may facilitate further research on the mechanisms underlying centrosome inheritance in ACD.

PMID:
42602968
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.

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