Authors
Leslie Atenas Arteaga Bruno, Josue Luis Medina Estrada, Maritza de Los Angeles Astudillo Melgar, Moises De la Cruz Cuevas, Marina Romero Navarrete
Published in
Cureus. Volume 18. Issue 7. Pages e112680. Epub Jul 14, 2026.
Abstract
Histoplasmosis is a systemic mycosis. In patients infected with HIV, the disseminated form represents one of the most severe presentations of the disease. While the infection primarily manifests in the pulmonary system, it can also present cutaneously or intestinally, posing a significant diagnostic challenge. We report the case of a 28-year-old male patient with a diagnosis of HIV and disseminated histoplasmosis (involving cutaneous, pulmonary, and intestinal systems). He presented with disseminated dermatosis, hepatosplenomegaly, pancytopenia, dysphagia, and subsequent gastrointestinal bleeding; skin and intestinal biopsies confirmed the diagnosis. The patient was treated with amphotericin B (sodium deoxycholate), resulting in a favorable clinical outcome. He was discharged with a subsequent regimen of oral antifungal therapy and antiretrovirals. Disseminated histoplasmosis remains a frequent opportunistic infection in patients living with HIV. Cutaneous manifestations are often nonspecific. In patients with severe immunosuppression, histoplasmosis should always be considered among the differential diagnoses.
PMID:
42603028
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.
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