Pathogenic Airway Bacteria and Local Immune Responses During Early-Life Asthma-Like Episodes.

Authors

Mathilde Bundgaard Svendsen, Tamo Sultan, Anton Kjellberg, Mathias Melgaard, Susanne Brix, Karen Krogfelt, Nilo Vahman, Ann-Marie Malby Schoos, Jakob Stokholm, Bo Lund Chawes, Klaus Bønnelykke, Jonathan Thorsen, Julie Nyholm Kyvsgaard

Published in

Allergy. Aug 15, 2026. Epub Aug 15, 2026.

Abstract

Respiratory tract colonization by the pathogenic airway bacteria Haemophilus influenzae, Streptococcus pneumoniae, and/or Moraxella catarrhalis has been linked to the pathogenesis of childhood asthma and exacerbations, but the underlying mechanisms remain unclear.
To investigate the association of H. influenzae, S. pneumoniae, and M. catarrhalis with airway immune responses during acute early-life asthma-like episodes and examine how these responses differ between children with and without asthma.
The study included 476 asthma-like episodes from 271 children aged 0 to 4 years from the COPSAC₂₀₁₀ mother-child cohort. Levels of 17 immune mediators covering Type-1, -2, and -17 and regulatory pathways were assessed in upper airway mucosal lining fluid while hypopharyngeal aspirates were collected for bacterial cultures and nasopharyngeal aspirates for viral PCR. Asthma was prospectively assessed until age 6 years.
Detection of H. influenzae during asthma-like symptoms was associated with elevated IL-1β, TNF-α, and IL-2, alongside decreased CXCL10 levels. Similar immune profiles were observed in children with and without asthma by age 3. Detection of S. pneumoniae and M. catarrhalis were not associated with significant changes in immune mediator levels; however, children with asthma by age 3 exhibited elevated IL-1β levels during detection of S. pneumoniae, a pattern not observed in children without asthma. No significant differences in mediator levels were observed in children with and without asthma at age 6.
Children with pathogenic bacterial detection in the airways during acute asthma-like episodes exhibit an increased proinflammatory immune response marked by increased IL-1β, IL-2 and TNF-α, which may promote chronic inflammation, possibly contributing to asthma development and exacerbations.

PMID:
42603086
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.