Patterns of radiological response to procarbazine and CCNU polychemotherapy in patients with oligodendroglioma.

Authors

Sophie Katzendobler, Luis Kuschel, Nicola Zieger, Frederic Thiele, Michael Schmutzer-Sondergeld, Dragan Jankovic, Roman Stürzl, Patrick N Harter, Robert Stahl, Darius Kalasauskas, Asgeir S Jakola, Nathalie L Albert, Emilie Le Rhun, Michael Weller, Florian Ringel, Jonathan Weller

Published in

Neuro-oncology advances. Volume 8. Issue 1. Pages vdag184. Epub Aug 06, 2026.

Abstract

To characterize the radiological response to procarbazine and CCNU (chloroethyl-cyclohexyl-nitrosourea) (PC) polychemotherapy in patients with oligodendroglioma.
In this retrospective single-center cohort study, patients with Central Nervous System World Health Organization (CNS WHO) grade 2 or 3 oligodendroglioma treated with PC between 2003 and 2019 were included. Tumor characteristics were assessed on magnetic resonance imaging (MRI) and [¹⁸F]Fluoroethyltyrosine positron emission tomography ([¹⁸F]FET PET) before and after completion of PC. The T1/T2 ratio was assessed to characterize diffuse versus sharply delineated MRI phenotype. Progression-free survival (PFS) and overall survival (OS) were analyzed.
Forty-six patients with a median follow-up of 118 months were identified. Median absolute T2 tumor volume was 52 cm³ (range 10-285) prior to PC and 29 cm³ (range 3-286) after. Median tumor volume decrease was -30% (range -96% to +113%). In treatment-naïve patients, median tumor volume decrease was -41% (range -92% to +14%) versus -7% (range -96% to +113%) in pretreated patients (P < .01). Stratification according to CNS WHO grade (P = .89) or contrast enhancement (P = .07) did not yield significant differences. The T1/T2 ratio was lower after PC (0.69 vs 0.50, P = .04), and higher T1/T2 ratios were associated with shorter PFS (P = .04) in multivariate analysis. On [¹⁸F]FET PET, there was a trend towards lower maximum tumor-to-brain ratios (TBRmax) after PC (P = .07).
PC polychemotherapy induces substantial tumor volume reductions in subsets of patients with oligodendroglioma, particularly in treatment-naïve patients. The observations that circumscript oligodendrogliomas may be associated with earlier progression and that PC treatment may induce a shift toward a more diffuse phenotype require prospective validation.

PMID:
42603070
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.

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