Authors
J Argüero, L Bayarri, L Bono, Ana Braslavsky, J P Santino, M L González, M M Marcolongo, C A S Parisi
Published in
Acta gastroenterologica Latinoamericana. Volume 56. Issue 2. Pages 196-207. Epub Jun 30, 2026.
Abstract
Eosinophilic esophagitis is poorly characterized in Latin America. We aimed to estimate its prevalence and describe its clinical, endoscopic, and histologic features, treatments, remission, and associated factors.Cross-sectional analysis of a retrospective-prospective registry. The study included adults with confirmed eosinophilic esophagitis between 2014 and 2025, defined by symptoms of esophageal dysfunction and ≥15 eosinophils per high-power field. Factors associated with histologic remission were explored using logistic regression.
A total of 129 adults were included (72.9% male; median age, 43 years). Prevalence was 36 per 100,000 health plan members (95% CI, 27 - 47), and median diagnostic delay was 8.21 months. Dysphagia (75.1%) and food impaction (63.2%) were the predominant symptoms. Frequent endoscopic findings included furrows (30.4%), edema (24.9%), and rings (23.4%); 49% had a normal endoscopy. Treatments included proton pump inhibitors (88%), topical corticosteroids (45%), and an elimination diet (39%). Clinical remission was 51.2% and histologic remission was 34.3%. Food sensitization was associated with histologic remission (adjusted odds ratio, 3.31; 95% CI, 1.26 - 8.73; p = 0.015). Among those who achieved histologic remission, 28% continued to have an incomplete clinical response.
The local prevalence was at the lower end of the pooled global estimate (40.04; 95% CI, 31.10 - 48.98) and below the 2017 - 2022 estimate (74.42; 95% CI, 39.66 - 109.19), and lower than contemporary estimates from the United States and Spain, with methodological and population-related caveats. Normal endoscopies reinforce the need for biopsies when eosinophilic esophagitis is suspected. Histologic remission in one-third of cases highlights the need to optimize treatment and follow-up.
PMID:
42602528
Bibliographic data and abstract were imported from PubMed on 15 Aug 2026.
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