Inducing Metabolic Dysfunction in Breast Cancer Cells Through Targeted Inhibition of α- and β-Glucosidase and Amylase: Novel Carbohydrate (C₈N) Isomers Designed via Intramolecular aza-Michael-Type Reaction.

Authors

Emel Karakılıç, Gökay Aydın, Gamze Güney Eskiler, Sinan Başçeken, Arif Baran

Published in

ChemMedChem. Volume 21. Issue 16. Pages e70422. Aug 27, 2026.

Abstract

Natural products such as glucosidase inhibitors and aminoglycoside antibiotics are target agents that play an important role in the development of new drugs. A novel class of glucosidase inhibitors based on aminocyclitols was synthesized using a new method. This method involves arranging the α-, β-unsaturated structure by attacking the ammonia compound on the acetate group in the γ-position forming, to form the amide in the β-position. The method has enabled the synthesis of new types of C₈N, such as C₇N (C₈N generally exhibits structural and characteristic biological properties similar to C₇N) compounds. After purification and structure elucidation of the resulting substances, α-, β-glucosidase, and amylase tests were performed against acarbose; additionally, an enzyme kinetic study of well-active compounds was conducted. Subsequently, the anticancer activity of substances was analyzed using a viability assay and AO/PI staining. Our results suggest that different derivatives of new carbosugar isomers exert potential enzymatic and anticancer activity against breast cancer cells.

PMID:
42603779
Bibliographic data and abstract were imported from PubMed on 16 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.