Generation of a human induced pluripotent stem cell line (HEBHMUi019-A) from a 67-year-old male Alzheimer's patient with APOE-ε4/ε4 genotype.

Authors

Jiajia Ma, Zilin Hua, Boyao Zhao, Jingrong Xu, Kexin Bao, Ruiyun Guo

Published in

Stem cell research. Volume 95. Pages 104082. Aug 13, 2026. Epub Aug 13, 2026.

Abstract

Apolipoprotein E (apoE), encoded by the polymorphic APOE gene, plays a key role in lipid transport and metabolism. The three major APOE alleles are ε2, ε3, and ε4, with ε4 being the strongest genetic risk factor for late-onset Alzheimer's disease. We generated human induced pluripotent stem cells from peripheral blood mononuclear cells of a 67-year-old male patient with Alzheimer's disease carrying the APOE ε4/ε4 genotype. The generated cell line displayed typical iPSC morphology, a normal karyotype, trilineage differentiation potential, and pluripotency-marker expression, providing a resource for investigating APOE ε4-associated disease mechanisms and preclinical therapeutic screening.

PMID:
42603521
Bibliographic data and abstract were imported from PubMed on 16 Aug 2026.

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