Hemiarch repair versus total-arch repair with frozen elephant trunk for acute type A aortic dissection: A propensity score-matched study.

Authors

Julin Zhang, Jili Li, Yaoye Chen, Xingrui Tao, Qianlei Lang, Zhefeng Kang, Jiuhong Li, Hao Niu, Xiangfeng Gong, Ruofan Zhou, Jia Hu, Wei Meng, Zhong Wu, Michael W A Chu, Zhenghua Xiao, Chaoyi Qin

Published in

JTCVS open. Volume 32. Pages 101945. Epub Jun 30, 2026.

Abstract

The optimal extent of arch repair remains controversial in acute type A aortic dissection. Although hemiarch replacement (HAR) may offer more favorable perioperative outcomes, total arch replacement with frozen elephant trunk (TAR with FET) may offer superior long-term outcomes. This study aims to compare these strategies in a contemporary single-center cohort.
Patients undergoing arch repair for acute type A aortic dissection between January 2020 and January 2025 were included. Propensity-score matching was used for further analyses. Primary outcomes included operative mortality and aortic reinterventions. Secondary outcomes included re-exploration for bleeding, renal failure, respiratory failure, neurologic complications, and aortic positive remodeling, defined as true lumen expansion greater than 50%.
Among 786 patients (171 hemiarch, 615 total arch), 272 patients were included in the matched cohort, comprising 136 matched pairs of HAR and TAR with FET, with a median follow-up of 3 years. Perioperative outcomes were comparable: operative mortality (5.1% HAR vs 7.4% TAR with FET; odds ratio [OR], 1.50; P = .442), renal failure (12.5% vs 8.8%; OR, 0.71; P = .353), respiratory failure (22.8% vs 25.7%; OR, 1.17; P = .579), and neurologic complications (13.2% vs 16.2%; OR, 1.29; P = .481). Meanwhile, 3-year survival (P = .420) and aortic reintervention rates (P = .135) were also comparable. Computed tomography angiography demonstrated superior aortic remodeling after TAR with FET replacement, with a greater true lumen ratio and a greater rate of true lumen expansion (28.7% vs 42.9%; OR, 0.54; P = .019). In a subgroup analysis of patients with acute malperfusion, perioperative mortality and major complications remained high overall. However, no significant differences were observed between HAR and TAR with FET in this subgroup.
HAR and TAR with FET were associated with similar perioperative outcomes and 3-year survival rate. Although aortic remodeling is superior in TAR with FET group, 3-year aortic reintervention rates were comparable. Our findings suggest that TAR may be considered more proactively in high-volume aortic centers; however, longer-term clinical benefits remain undefined. Further study is warranted.

PMID:
42604310
Bibliographic data and abstract were imported from PubMed on 16 Aug 2026.

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