Metabolic Symbiosis Between Cancer Cells and Endothelial Cells: A Key Driver of Tumor Angiogenesis.

Authors

Jacinta Serpa

Published in

Advances in experimental medicine and biology. Volume 1501. Pages 165-189.

Abstract

This chapter explores the critical role of angiogenesis in cancer, focusing on the metabolic processes involved in angiogenesis, particularly the metabolic remodeling of endothelial cells (ECs) and the symbiosis between cancer cells and ECs, which drive vascular development. Key topics include the influence of hypoxia and oxidative stress, and the reliance on different metabolic sources on EC function, as well as how various pro-angiogenic factors contribute to tumor vascularization. The importance of metabolic flexibility in ECs and its implications for cancer treatment will also be highlighted.

PMID:
42435170
Bibliographic data and abstract were imported from PubMed on 17 Aug 2026.

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