Diterpenoids from Excoecaria agallocha and their cytotoxic activity.

Authors

Ya Li, Xu-Xin Zhu, Zi-Jian Tan, Kun Gao, Jian-Min Yue

Published in

Fitoterapia. Pages 107443. Aug 16, 2026. Epub Aug 16, 2026.

Abstract

A phytochemical investigation on the twigs and leaves of Excoecaria agallocha led to the discovery of eight undescribed diterpenoids, along with 21 known analogues. Their structures were elucidated based on comprehensive HRESIMS, HREIMS, and NMR spectroscopic analyses. The cytotoxicity of some isolates was tested against human lung cancer cells (A549) and human promyelocytic leukemia cells (HL-60). Compounds 2 and 4 showed moderate cytotoxic effect against HL-60 with IC₅₀ values of 7.60 ± 2.67 μM and 12.64 ± 0.13 μM, respectively. However, other tested compounds displayed little or weak inhibitory effects against A549 and HL-60 with inhibition rate less than 50% at the concentration of 20 μM.

PMID:
42604695
Bibliographic data and abstract were imported from PubMed on 17 Aug 2026.

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