Phospholipid-modified glycogen nanoparticles for synergistic chemo-photothermal treatment of glioblastoma.

Authors

Yumeng Bao, Junsong Guo, Hao Li, Juan Zhou, Jinghua Chen

Published in

Nanoscale. Aug 14, 2026. Epub Aug 14, 2026.

Abstract

Glioblastoma multiforme (GBM) remains one of the most aggressive central nervous system malignancies, with therapeutic efficacy severely constrained by the blood-brain barrier (BBB), which limits drug delivery to the tumor site, and by the lack of tumor-specific targeting, leading to off-target effects and inadequate intratumoral accumulation. To address these interconnected challenges, we designed a dual-targeted biomimetic nanoplatform (GIM@Lip-Bio/FA) using glycogen as a biodegradable core for co-loading methotrexate (MTX) and IR780, followed by coating with a lipid layer sequentially modified with biotin and folic acid (FA) to enable active transport across the BBB and selective recognition by glioma cells. The resulting nanoparticles exhibited a uniform size, excellent stability, and significantly enhanced cellular uptake mediated by SMVT and folate receptor α (FRα). Notably, the nanoplatform demonstrated efficient BBB penetration and precise tumor accumulation in orthotopic GBM models. Upon near-infrared irradiation, synergistic chemo-photothermal therapy was achieved, leading to effective suppression of tumor growth, with a 76% reduction in tumor volume compared to the control group. This work presents a promising strategy for targeted GBM therapy.

PMID:
42605539
Bibliographic data and abstract were imported from PubMed on 17 Aug 2026.

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