Cytogenetic Characteristics of Chronic Lymphocytic Leukemia Patients: A Single-Center Study From Morocco.

Authors

Monsif Fadi, Yasmine El Ouafa, Chaimaa Hilali, Fatima Azzahra Lahlou, Nouama Bouanani

Published in

Cureus. Volume 18. Issue 7. Pages e112825. Epub Jul 16, 2026.

Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia, characterized by significant clinical and biological heterogeneity. Cytogenetic abnormalities play a crucial prognostic role and influence treatment decisions. This study aimed to characterize the cytogenetic profile of CLL patients in a Moroccan tertiary hospital and to describe the distribution of major chromosomal abnormalities.
We conducted a retrospective descriptive study including patients diagnosed with CLL between January 2023 and December 2025 in the Hematology Department. Clinical, demographic, and cytogenetic data were collected from medical records. Cytogenetic analysis was performed using conventional karyotyping and/or fluorescence in situ hybridization (FISH), according to routine availability in daily practice.
A total of 53 patients were included, with a slight male predominance, comprising 28 (52.8%) men and 25 (47.2%) women, resulting in a male-to-female ratio of 1.12. The median age was 57 years, and the mean age was 56.2 years. Conventional karyotyping was performed in 20 of 53 patients (38%). Among the patients who underwent conventional karyotyping, 16 (80%) had a complex karyotype and four (20%) had a normal karyotype, corresponding to 30.2% and 7.5% of the overall cohort, respectively. FISH analysis was available for 46 (86.8%) patients and detected cytogenetic abnormalities in 24 (45.3%) patients. The most frequent abnormality was del(17p)/TP53, identified in 17 (47.2%) patients, followed by del(11q) in nine (25%) patients, del(13q14) in six (16.7%) patients, trisomy 12 in three (8.3%) patients, and del(14q) in one (2.8%) patient. Only one (2.8%) patient had an isolated 13q deletion, which is generally associated with a favorable prognosis.
Cytogenetic abnormalities were frequent in this cohort, mainly TP53/17p deletion and complex karyotype. These results support routine cytogenetic assessment for accurate risk stratification and treatment planning in CLL.

PMID:
42605271
Bibliographic data and abstract were imported from PubMed on 17 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.