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Photodynamic antimicrobial and antineoplastic therapy in veterinary medicine: current status, challenges, and perspectives.

Created on 17 Aug 2026

Authors

Jiaxu Lu, Shuyao Zhu, Aftab Shaukat, Shuhao Bian, Xiaoxuan Shi, Di Zhu, Jingyu Wang, Aoyun Li, Hongyu Dai, Fang Liu, Haiju Dong, Xiangqian Zhang

Published in

The veterinary quarterly. Volume 46. Issue 1. Pages 2713493. Dec 31, 2026. Epub Aug 16, 2026.

Abstract

Significant causes of morbidity in veterinary medicine are tumourigenic diseases and pathogenic infections, which pose significant threats to animal health. Traditional methods for treating tumours and bacterial infections primarily involve chemotherapy and antibiotic therapy, both of which are associated with drug resistance and adverse effects. Photodynamic therapy (PDT) is gaining increasing interest in veterinary clinical practice because of its distinctive benefits such as spatiotemporal selectivity, low toxicity, fewer negative effects, and reduced risk of drug resistance. This review summarises the fundamental principles of PDT and its applications in combating tumours and microbial infections in veterinary practice involving companion animals, livestock, wildlife, and reptiles. It is worth noting that the existing clinical evidence is limited by very small sample sizes and the absence of comparator groups; however, these studies have provided a preliminary theoretical foundation and technical reference for further clinical development of PDT. Moreover, the opportunities and challenges associated with PDT in veterinary clinical practice are discussed herein.

PMID:
42605128
Bibliographic data and abstract were imported from PubMed on 17 Aug 2026.

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