Visible-light-promoted regioselective silylation/cyclization of cyclopropanol-tethered sulfonamides for the synthesis of silyl-substituted benzazepines.

Authors

Shihua Zhao, Xuesong Wang, Shifang Li, Jiemin Zhao

Published in

Chemical communications (Cambridge, England). Aug 17, 2026. Epub Aug 17, 2026.

Abstract

A visible-light-promoted regioselective silylative cascade cyclization of cyclopropanol-tethered benzenesulfonamides with hydrosilanes is reported. This transformation, enabled by Ir photoredox catalysis and PhI(OAc)₂, proceeds smoothly under blue LED irradiation at room temperature, providing efficient access to silyl-substituted benzazepine derivatives. The reaction features mild conditions, broad substrate scope, good functional group tolerance, and compatibility with diverse hydrosilanes. Scale-up synthesis and further product derivatizations highlight the synthetic utility of this method.

PMID:
42605593
Bibliographic data and abstract were imported from PubMed on 17 Aug 2026.

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