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Navigating Voriconazole in Pediatrics: Dosing Dilemmas and Monitoring Madness.

Created on 17 Aug 2026

Authors

Daniel J Trisno, Laura Bio, Hayden T Schwenk

Published in

Pediatric blood & cancer. Pages e70628. Aug 17, 2026. Epub Aug 17, 2026.

Abstract

Safe and effective use of voriconazole in children necessitates therapeutic drug monitoring (TDM) of serum concentrations given the pharmacokinetic variability amongst these patients. Informed by an internal review of voriconazole TDM practices revealing suboptimal performance, our aim was to improve the proportion of voriconazole TDM obtained as a trough at steady state (trss). Revision to our internal lab order and creation of a triazole TDM guidance document resulted in a higher proportion of voriconazole trss. These interventions are a first step to future improvement in time to therapeutic voriconazole trss in pediatric patients.

PMID:
42605876
Bibliographic data and abstract were imported from PubMed on 17 Aug 2026.

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