Authors
Ruonan Wu, Yuyang Zhong, Siyu Tu, Meijuan Fan, Yu Lu, Zhenyu Wang, Shendong Ren, Zhanhong Guo, Xiang Wu, Chengfeng Zhu
Published in
Inorganic chemistry. Volume 65. Issue 32. Pages 18730-18737. Aug 17, 2026.
Abstract
While the enantiomeric separation of β-nitroalcohols from racemic mixtures is paramount to the manufacture of enantiopure pharmaceuticals, developing chiral separation materials that resolve these compounds with both high enantioselectivity and broad substrate scope remains a massive challenge. Herein, we report a homochiral porous coordination polymer, S-1, constructed from a C2-symmetric phenylalanine-derived ligand with a well-balanced combination of flexibility and rigidity. Assembled with tetrameric Cu4 clusters, S-1 features open channels of 8 Å × 14 Å, in which a confined amphiphilic chiral cavity decorated with peptide functional groups is periodically distributed. When utilized as a chiral adsorbent, this porous material is capable of resolving a series of pharmacologically important aromatic β-nitroalcohols with enantioselectivity up to 99.8%. Furthermore, the chiral adsorbent can be easily recovered and reused for five cycles without any apparent loss of enantioselectivity, demonstrating excellent recyclability. This work not only provides a reliable strategy for constructing amino acid-based porous coordination polymers but also offers a promising platform for targeted β-nitroalcohol resolution.
PMID:
42606262
Bibliographic data and abstract were imported from PubMed on 17 Aug 2026.
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