Organocatalytic stereoselective synthesis of amino acid-fused quinazolinone based triazacyclic new chemical entities.

Authors

Sachin D Mahale, Zeel Y Surati, Santosh B Mhaske

Published in

Organic & biomolecular chemistry. Aug 17, 2026. Epub Aug 17, 2026.

Abstract

Chiral polycyclic quinazolinone scaffolds bearing multiple stereocenters are prevalent in natural products and pharmaceuticals, making their asymmetric synthesis highly desirable. Herein, we report the design and stereoselective synthesis of novel quinazolinone-fused triazacyclic frameworks integrating two biologically significant motifs into a single, densely functionalized scaffold via an efficient, transition metal-free, organocatalytic one-pot protocol. The use of a chiral Brønsted acid catalyst facilitates higher diastereoselectivity, enabling the generation of a diverse library of diastereomerically enriched polycyclic quinazolinone based new chemical entities (NCEs) in good yields under mild conditions. Furthermore, the protocol should be applicable to other imine substrates, offering a potential route to diverse complex molecular scaffolds of pharmaceutical interest.

PMID:
42606223
Bibliographic data and abstract were imported from PubMed on 17 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.