Authors
Ziliang Ding, Yukun Wei, Xiaoxiao Yao, Fengli Guo, Shujian Xu, Yong Han, Pengfei Gu
Published in
Journal of endocrinological investigation. Aug 17, 2026. Epub Aug 17, 2026.
Abstract
The optimal surgery for isthmic papillary thyroid carcinoma (IPTC) remains controversial. This meta-analysis compared oncologic and complication outcomes between total (TT) and limited thyroidectomy (LT).
PubMed, Embase, and Web of Science were searched up to December 2025 for retrospective cohort studies comparing TT and LT for IPTC. Outcomes were recurrence and complications. Risk ratios (RR) with 95% confidence intervals (CI) were calculated using random-effects models.
Eight studies comprising 1,285 patients (696 LT, 589 TT) were included. Recurrence rates were comparable (LT: 6.61% vs. TT: 4.07%; pooled RR = 1.40, 95% CI: 0.79-2.47, P = 0.25; I2 = 13%). LT significantly reduced overall complications (RR = 0.39, 95% CI: 0.30-0.50, P < 0.00001), including transient complications (RR = 0.39), parathyroid dysfunction (RR = 0.30), and hoarseness (RR = 0.44).
In selected patients with isthmic papillary thyroid carcinoma, limited thyroidectomy may achieve similar short-term oncologic outcomes to total thyroidectomy while reducing complications, although the available evidence remains insufficient to establish oncologic equivalence. However, given methodological limitations, these findings are hypothesis-generating and require validation through prospective studies with standardized outcome definitions and extended follow-up.
PMID:
42606812
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.
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