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Disarming a pathogen with programmable phage-derived particles.

Created on 18 Aug 2026

Authors

Siqi Yang, Brady F Cress

Published in

Trends in microbiology. Aug 17, 2026. Epub Aug 17, 2026.

Abstract

Shiga toxin-producing Escherichia coli (STEC) presents a therapeutic dilemma because antibiotic treatment induces prophage-encoded Shiga toxin expression. Galtier et al. engineer phage-derived particles with programmable cell specificity, genetic cargo, and CRISPR guide RNAs that destroy stx while killing STEC in animal models.

PMID:
42608251
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.

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