Authors
S A S, P Kakada, M Yuwanati
Published in
International journal of oral and maxillofacial surgery. Aug 17, 2026. Epub Aug 17, 2026.
Abstract
The aim of this systematic review was to assess the global incidence of submandibular gland (SMG) involvement in oral squamous cell carcinoma (OSCC) and its impact on the prognosis. Studies reporting SMG involvement in OSCC were identified in the PubMed, Scopus, Web of Science, and Cochrane CENTRAL databases. All non-duplicate studies were screened against the inclusion criteria to determine eligibility. Study characteristics and outcomes data were extracted from the included studies. The pooled incidence of SMG involvement per OSCC case and per SMG was estimated by random-effects meta-analysis; subgroup analyses according to study design were also performed. Publication bias was assessed by funnel plot. A descriptive analysis of the prognostic impact of SMG involvement on OSCC was performed. Overall, 32 studies were included, involving 6495 OSCC patients who underwent 6790 SMG removals. The pooled incidence of SMG involvement per OSCC patient was 0.021 (95% confidence interval 0.015-0.028) and per SMG was 0.020 (95% confidence interval 0.014-0.027). Although involvement of the SMG impacts the overall prognosis, the number of studies providing survival data is limited. This review identified a low incidence of SMG involvement in OSCC, and when present, this was primarily due to direct tumour invasion or extracapsular spread. While data on the prognostic significance of SMG involvement remain limited, existing evidence suggests that selective preservation of the SMG may be oncologically safe in OSCC.
PMID:
42608235
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 7
- Comments 0