Neuropathological Findings Following Failure of Laser Interstitial Thermal Therapy for an Epileptogenic Cerebral Cavernous Malformation.

Authors

Alberto Pietrantoni, Roberta Di Giacomo, Michele Rizzi, Valeria Cuccarini, Fabio Martino Doniselli, Rachele Colombo, Gianluca Marucci

Published in

Neuropathology and applied neurobiology. Volume 52. Issue 4. Pages e70099.

Abstract

We describe the case of a 32-year-old woman with focal drug-resistant epilepsy, who underwent surgical resection of a cerebral cavernous malformation (CCM), previously treated with laser interstitial thermal therapy (LITT), after experiencing seizure recurrence. Histological findings after LITT have been rarely described. We report and discuss neuropathological findings to explain post-LITT seizure recurrence, with a focus on extensive hemosiderin deposition and a minimal residue of the original CCM. This illustrative case may aid the comprehension of histological bases underlying the LITT failure in seizure relief.

PMID:
42608148
Bibliographic data and abstract were imported from PubMed on 18 Aug 2026.

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